The Memorandum of Agreement - signed at the Dubai Airshow with Dubai South - was confirmed at a private signing ceremony.
"I congratulate Boeing on its strategic decision to establish its regional headquarters at Dubai South - a city that embodies Dubai's aerospace vision," said Ahmed Bin Saeed Al Maktoum, chairman of Dubai Aviation City Corporation.
"I am confident that the new address will deliver a solid advantage to Boeing as it seeks to expand its footprint in Dubai and in the region," he added.
"Boeing is the world's leading aerospace company, and to ensure our regional competitiveness, we have taken a strategic decision to establish our regional headquarters in what will become an unrivaled logistics and aviation hub," said Dennis Muilenburg, Boeing president and CEO.