The report outlined evidence of systematic cheating with the consent of the government in Moscow, noting that drug tests for athletes were conducted at a Russian lab which totally lacked credibility.
"It's pretty disturbing," said former WADA chief Richard Pound, who headed the three-man commission, adding that the extent of the cheating was "worse than we thought".
The panel's findings called for athletics' governing body (IAAF) to suspend Russia's athletics body (ARAF) and declare it "non-compliant" with globally agreed doping regulations.
"I want an explanation," Coe said yesterday on a conference call. "I am completely shocked by the allegations."
"My instinct remains to encourage engagement not isolation, but the extent of what's being said, I need to seek (IAAF) council support to have them (Russia) report back by the end of the week."
The IAAF Council are due to meet Friday to discuss the crisis facing the Olympic's flagship sport, and the country faces a provisional suspension at the next IAAF meeting this month in Monaco.