The Bryan brothers finally prevailed with a scoreline of 6-7 (4-7) 6-4 6-3 5-7 6-3 in a battle that lasted for two hours and 48 minutes.
It is the experience of the US twins at this level of the competition that helped them blow away the Indo-French pair in the fifth set.
A decisive 3-0 lead early in the final set sealed the match in favour of the Bryans despite a brave fightback from Bopanna and Roger-Vasselin.
It started well for Bopanna and his French partner as they won the first on tie-breaker at 7-4. Bopanna did hit some booming aces. The Bryans did well to comeback in the next two sets as they broke serve once in the second set and twice in the third set to win them 6-3 and 6-4 respectively.
The Indo-French pair did well to get a break of serve in the fourth set that they won 7-5.