The Indo-American pair put up a spirited fight before losing 4-6 6-7 (4) in the opening round of the USD 5,030,408 hard court event.
India's Mahesh Bhupathi and his Canadian partner Daniel Nestor, seeded third, have been pitted against Feliciano Lopez of Spain and Milos Raonic of Canada for their first round clash.
Leander Paes and his Austrian partner Jurgen Melzer, seeded seventh, face Benoit Paire of Frace and Swiss Stanislas Wawrinka in their tournament-opener.