"Hieronymus Bosch - Visions of Genius" wrapped up yesterday in the southern Dutch town of Den Bosch with more than 421,000 people visiting over the last three months.
"It was easily the best visited exhibition in the almost 180-year history of the Noordbrabants Museum," the museum said in a statement.
A feature-length film about the event is set to screen next year in more than 2,000 cinemas in 42 countries across the world.
"Never before had so many works of Hieronymus Bosch come back to 'his' city, Den Bosch, the place where the paintings were created more than 500 years ago," the museum said.
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The exhibition's opening kicked off a year of events in the medieval town to honour its most famous son, who was born Jheronimus van Aken in around 1450 and died in 1516, 500 years ago this year.
Bosch's most famous work, a triptych called "The Garden of Earthly Delights" which journeys from a scene of Adam and Eve in the Garden of Eden to descend into a terrifying vision of hell - was, however, not on display.
But in a major victory for the museum, the Prado did agree to allow Bosch's "The Haywain" to leave Spain for the first time in 450 years.
It was on display among other important works such as "Death and the Miser" currently owned by the National Gallery in Washington, and "The Ship of Fools" from the Louvre in Paris.