The rapper, also known as Shad Moss, will play a computer hacker named Brody 'Baby Face' Nelson, reported Entertainment Weekly.
In the show, his character is ordered by a judge to work with Special Agent Avery Ryan (Patricia Arquette), or go to prison.
"Bow Wow is a gifted young actor who will have the responsibility, through his character, to set an example for young people who watch the show to 'do what's right' even when you know 'nothing but wrong'," creator of the 'CSI' franchise Anthony E Zuiker said.
"It will be a redemption story and a cautionary tale all wrapped into one. The role of Nelson required someone with deep acting chops and off-the-charts smarts. Shad Moss is a unique talent that possesses both."