In reply to Mumbai's first innings total of 233, UP resumed the day on 22 for one and started losing wickets at regular interval.
Medium pacer Tushar Deshpande took three for 66, while Abhishek Nayar (2/19), Vishal Dabholkar (2/26) and Aditya Dhumal (2/33) chipped in with two scalps each to run through the UP batting line-up.
Only Rinku Singh and lower-order batsman Kuldeep Yadav scored a half-century each but could not take the team past Mumbai's modest first innings total.
Imtiaz Ahmed (19) also played a crucial knock lower down but still failed to acquire a lead for Uttar Pradesh.
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In their second innings, Mumbai did not get off to an ideal start, losing two wickets -- Kaustubh Pawar (29) and Dhumal (0) -- to finish the day on 51 for two in 24 overs.
At stumps, opener Akhil Herwadkar was batting on 15 and giving him company at the other end was Shreyas Iyer on three.
Mumbai: 233 & 51 for two in 24 overs
Uttar Pradesh 1st innings: 225 all out in 76.1 overs (Rinku Singh 70, Kuldeep Yadav 50; Tushar Deshpande 3/66, Abhishek Nayar 2/19, Vishal Dabholkar 2/26).
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