The finding, made in an examination of a 48-year-old man who suffered a stroke, provides the first causal clinical evidence that an area of the brain called the anterior insula "plays an instrumental role in love," said neuroscientist Stephanie Cacioppo, from the University of Chicago.
In an earlier paper that analysed research on the topic, Cacioppo and colleagues defined love as "an intentional state for intense [and long-term] longing for union with another" while lust, or sexual desire, is characterised by an intentional state for a short-term, pleasurable goal.
"This distinction has been interpreted to mean that desire is a relatively concrete representation of sensory experiences, while love is a more abstract representation of those experiences," said Cacioppo, a research associate and assistant professor in psychology.
The new data suggest that the posterior insula, which affects sensation and motor control, is implicated in feelings of lust or desire, while the anterior insula has a role in the more abstract representations involved in love.
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The studies showed consistently that the anterior insula was associated with love, and the posterior insula was associated with lust.
"We reasoned that if the anterior insula was the origin of the love response, we would find evidence for that in brain scans of someone whose anterior insula was damaged," Cacioppo said.
In the study, researchers examined a 48-year-old heterosexual male in Argentina, who had suffered a stroke that damaged the function of his anterior insula.
He was matched with a control group of seven Argentinian heterosexual men of the same age who had healthy anterior insula.
The patient with the damaged anterior insula showed a much slower response when asked if the women in the photos could be objects of love.
"The current work makes it possible to disentangle love from other biological drives," the authors wrote.
The findings are published in the journal Current Trends in Neurology.