Brand and Perry divorced in 2012 after 14 months of marriage, reported Aceshowbiz.
"Oh my God. I'm living, like, this life of the very thing I detest: vapid, vacuous celebrity," said Brand, who looked emotional, while footage of him and Perry walking through a group of paparazzi appeared on screen.
His rant was immediately followed by footage of the 31-year-old "Part of Me" singer saying, "I don't want to give all this up."
The 40-year-old comedian showed a surprised facial expression when he heard what Perry said.