A second half strike from Santos player Lucas Lima salvaged a vital point for Brazil yesterday after Argentina had taken the lead midway through the half thanks to an Ezequiel Lavezzi strike.
Lavezzi's Paris Saint-Germain team-mate David Luiz was sent off for a second yellow card in the dying minutes but Brazil hung on for the draw.
The result leaves Argentina winless after three games of South America's marathon qualifying campaign, with only two points from a possible nine.
Argentina, missing a glut of injured stars including Lionel Messi and Sergio Aguero, started the stronger against a Brazil side who welcomed back suspended striker Neymar.
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Neymar however was largely anonymous for long periods as Argentina got on top early on and opened up Brazil with ease on several occasions.
The only surprise was that it took Argentina more than half an hour to get on the scoresheet. The goal came after superb interplay between Argentina's powerful attacking front three.
The Napoli striker looked up and picked out Lavezzi with a superb low cross for the France-based star to ram past Alisson Becker for 1-0 on 34 minutes.