The programme will be rolled out in the southern state of Parana, said the maker of the Dengvaxia vaccine, which is the result of 20 years of research and 1.5 billion euros ($1.7 billion) of investment.
"We will vaccinate all individuals 15-27 years of age in 28 municipalities and 9-44 years of age in the two municipalities with the top dengue burden in our state over the next three weeks," Parana Health Secretary Michele Caputo Neto said in a Sanofi statement.
Sanofi said the campaign was the "first dengue immunisation public programme in the Americas".
The vaccine has been approved in Mexico, the Philippines, El Salvador and Costa Rica.
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In Parana state, home to 10 million people, cases of dengue fever and deaths due to the disease have tripled in recent years, according to Sanofi.
The mosquito-borne viral disease killed 863 people in Brazil in 2015, a 82.4 percent increase on the previous year.
Asia currently bears 70 percent of the global burden of the disease. In April Sanofi launched a public immunisation programme against dengue in the Philippines.
Dengvaxia is produced in France in a facility which should be able to produce 100 million doses per year when at full capacity.
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