In addition to the show taking best drama, Bryan Cranston picked up his fourth lead-actor Emmy for playing teacher-turned-drug kingpin Walter White last night.
Aaron Paul garnered his third supporting-actor award, co-star Anna Gunn became a two-time winner, and the show was also honoured with a writing award.
"Thank you so much for this farewell to our show. You have been very kind to us indeed," said creator Vince Gilligan.
Gunn pointed out her TV husband Cranston and called him "the baddest and the best human being," and the first guy Paul thanked was Gilligan.
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Cranston joked that even he thought about voting for 'True Detective' star - and recent Oscar-winner Matthew McConaughey.
"I don't know why I've been blessed. I love to act and I will do it to my last breath.
"I'd like to dedicate this word to all the Sneaky Petes (his childhood nickname) of the world who thought that settling for mediocrity was a good idea because it was safe. Don't do it - take a chance, find a passion, fall in love," Cranston said.
"I don't know how else to say it, but 'Modern Family' has been a big beautiful dream over the past five years, and we thank you for not waking us up," said creator Steve Levitan.
Burrell had words ready when he took the stage, but instead read a speech done by his TV kids.
"I should probably thank my wife because she's super pretty" and about his kids, whom he sometimes brings to the set. "They're cute, but they're just not 'I can support my whole family' cute."
Jim Parsons won the Emmy for outstanding lead actor in a comedy. It's his fourth win in the category, all for his performance in 'The Big Bang Theory'.