Australian Immigration Minister Scott Morrison said the asylum-seekers escaped yesterday evening but were quickly rounded up by private security contractors at the facility, one of two remote Pacific camps used in Canberra's punitive off-shore detention policy.
Under the scheme, aimed at deterring people-smugglers, any asylum-seeker arriving by boat or intercepted at sea is transferred to Manus or Nauru for processing and permanent resettlement outside Australia.
Morrison said power poles and fences were toppled during the fracas, and bunk beds smashed to fashion makeshift weapons, but no buildings were destroyed.
"As at this morning, five of those transferees remained at the clinic. A number of G4S (security contractor) staff also sustained minor injuries," Morrison told reporters.
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He said he did not yet have a full report about the medical conditions of those who were treated.
Refugee activist Ian Rintoul said a number of the asylum-seekers had suffered broken hands and baton injuries, adding that one "has 70 stitches in his head", indicating a "use of force last night out of all proportion".
"The imposition of the detention centre on Manus Island has created local tensions from the very start. The lack of transparency about resettlement has added to the tensions," he said.
The breakout followed a tense meeting at the centre between detainees and officials from Papua New Guinea's immigration and citizenship authority (ISCA) to discuss their fate if they were found to have a genuine refugee claim.
Morrison said detainees "became agitated and commenced chanting" after they were informed they would be resettled in PNG and "a third country option will not be offered".
Though security staff used "personal protection gear", Morrison said "no batons or other weapons were in situ". He would not clarify what the gear was and whether it included capsicum spray.