In what media commentators have dubbed the "trial of the century", eight people will appear at the Old Bailey in London for the start of up to four months of hearings on a scandal that shook the British establishment and rocked Murdoch's media empire and the entire British newspaper industry.
The charges range from illegally hacking the mobile phone voicemails of more than 600 victims including a murdered schoolgirl and celebrities such as Paul McCartney, plus bribing public officials for stories and hiding evidence.
The trial will formally open tomorrow but the prosecution's opening statement is expected to be delayed by the selection of a jury and by legal arguments.
The main players are Brooks, the flame-haired former chief executive of Murdoch's British newspaper operations, and Coulson, the journalist-turned-media-lynchpin for Cameron.
More From This Section
Brooks, 45, who rose from a secretary to edit the News of the World and its daily sister paper The Sun while becoming one of Murdoch's closest confidantes, denies phone hacking, conspiracy to commit misconduct in a public office, and perverting the course of justice.
Coulson, 45, a former News of the World editor, denies hacking and paying officials for a Buckingham Palace phone directory containing the royal family's contact details.
Also on trial are former News of the World managing editor Stuart Kuttner and head of news Ian Edmondson, who both deny phone hacking.
The final defendant is royal editor Clive Goodman, who is charged along with Coulson for bribing officials and also pleads not guilty.