The trip marks their second visit to Canada, following their first tour in 2011 just two months after their marriage.
The family arrives in Victoria, the capital of British Columbia, on September 24, for an eight-day visit that will take them all the way to the city of Whitehorse in the Yukon, according to an itinerary released by the Canadian government.
Governor General David Johnston, the representative of Queen Elizabeth II in Canada, will welcome the couple, who plan to address environmental issues and the mental health of native peoples and children.
The trip marks the first royal tour for Princess Charlotte, whose is 16 months old, and the second for three-year-old Prince George, who has already been to Australia and New Zealand in 2014, according to the BBC.
During their 2011 trip to Canada, William and Kate toured several eastern provinces before heading west to Alberta and the Northwest Territories.