The all-star release, "Hands" -- a charity single from Interscope Records with support from GLAAD -- was conceived by hit songwriter Justin Tranter, co-writer of pop star Justin Bieber's "Sorry" and hits for Gomez, DNCE, Fall Out Boy and Stefani, reported Billboard.
The June 12 attack at the gay nightclub in Orlando, which killed 49 people and injured 53, is the deadliest mass shooting in American history.
"Hands" will arrive on iTunes. Proceeds will be distributed by Equality Florida Pulse Victims Fund, the GLBT Community Center of Central Florida and GLAAD.