The 31-year-old singer said she is ready for the two-year stint at the Planet Hollywood casino, which kicks off later this year, reported Ace Showbiz.
Spears will sing live for the show, after it was previously reported that she 'hadn't had that conversation' with the venue.
"I am very ready for this. I'm ready physically, mentally - definitely. I love Las Vegas, and the energy is really, really good. The show will be completely different from what everybody might be expecting," Spears said.
"She's in the physical shape and vocal shape to sing the entire show," Kurt Melien, VP of Entertainment for Caesars, added.
Spears' 'Piece of Me' Vegas show will include snow, water and rain.