The 28-year-old has played through the pain of a long-standing patella tendonitis problem but will now go under the knife on September 4.
"The ECB medical team confirmed that England pace bowler Stuart Broad is to have surgery on his right knee on Thursday September 4. A rehabilitation and recovery programme will be determined following the operation," a statement issued by the ECB said.
However, though no specific time frame for his recovery was given after the operation, Broad is set to start a rehabilitation plan that will last for up to 14 weeks, Sky Sports reported.
"I've seen the surgeon 2day and now def having surgery on my troublesome knee 4th Sep I've been due for a while so can't wait to get sorted," he wrote on the social networking site.
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The Nottinghamshire seamer had already been ruled out of the one-day series against India having put off the procedure to allow him to play through a busy summer schedule with England.
"At any stage in the last 18 months, I could have had the op and it's at the stage where it needs to be done," he said after taking 6/25 on the opening day of the fifth Test at the Oval.