The actor beat Jon Hamm ('Mad Men'), Kevin Spacey ('House of Cards'), last year's winner Jeff Daniels ('The Newsroom'), Matthew McConaughey and Woody Harrelson, ('True Detective') to win the outstanding actor trophy at the 66th Emmy Awards.
Cranston has earlier won the award, also for 'Breaking Bad', three years in a row, in 2008, 2009 and 2010.
The 58-year-old actor, who played Walter White in the crime series, also received the honour for his role as the producer of 'Breaking Bad' as the show was announced the best drama series, said The Hollywood Reporter.
The actor dedicated the trophy "to all the Sneaky Petes of the world who thought that settling for mediocrity was a good idea because it was safe. Don't do it - take a chance, find a passion, fall in love."
'Breaking Bad', which debuted in 2008, ended its run last year with the fifth season. The drama entered the Guinness World Records as the highest rated show of all time.