"I called and left a message and they called me back" from the International Space Station, a toned Bullock said at the Venice film festival after a press screening of the film.
"They were incredibly helpful," she said.
"They gave me an inside visual as to why they chose what they do for a living, their love for what is beyond our planet."
The 3-D sci-fi thriller sees Clooney and Bullock as astronauts who are flung into dark, deep space when a debris shower destroys their shuttle.
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Clooney, dashing in a light grey suit, joked that he had "done yoga and drunk my way into the part" and said the biggest challenge was learning how to "move slowly to mimic body movement in space while speaking quickly".
Directed by Mexico's Alfonso Cuaron of "Children of Men" fame, the film induces nail-biting anxiety, with terrifying shots from inside the astronauts' helmets as they spin wildly and lose all radio contact with Earth.
"The idea was for a film in which we could strip the narrative down as much as possible... A story of just two characters in a very hostile environment who undergo a journey, a metaphor the audience could connect to," he said.
Cuaron invented new filmmaking techniques to depict spacewalking, including shooting inside a giant cube to evoke constantly shifting light sources.
"We had advisors, scientists and physicists teaching the cast how things would react in space. A lot of the shots required the actors to be isolated, it was a very abstract way for them to perform," he said.
Bullock plays Dr. Ryan Stone, a medical engineer on her first mission who relies on veteran astronaut Matt Kowalsky (Clooney) to hold on to her sanity and try to survive despite her rapidly dropping oxygen levels.
A soundtrack dominated by her racing heartbeat and the deafening silence of space is punctuated by jokes from Kowalsky: "Half of North America just lost its Facebook", he cracks as debris takes out communication satellites.