"It was a very bad head-on collision. We lost 26 people in the accident," Leonard Kimaiyo, police chief for the southern town of Kibwezi said.
Another senior officer said the bus, heading to Mombasa, was overtaking several vehicles when it collided with an oil tanker.
Kenya has a poor road safety record, with up to 3,000 people killed each year according to police. The World Health Organization puts the toll at 12,000.
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