The long-awaited US Senate report released Tuesday on the program of harsh treatment and torture of detainees said Bush only learned details of it in 2006, four years after it started in the wake of the 9/11 attacks on New York and Washington.
Detainees were beaten, waterboarded -- some of them dozens of times -- and humiliated through the painful use of medically unnecessary "rectal feeding" and "rectal rehydration", the report said.
Speaking to Fox News, Cheney denied Bush was kept out of the loop. He said the then-president "was in fact an integral part of the program and he had to approve it."
Bush has yet to speak out publicly on the Senate report, which has drawn scathing criticism worldwide of what the CIA has called "enhanced interrogation techniques", amid and calls for those involved to face trial.
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The CIA deliberately misled Congress and the White House about the value of the intelligence its interrogators were gathering, the report concluded.
But Cheney did not mince his words in rejecting that.
The investigation was "deeply flawed" and "didn't bother to interview key people involved in the program," he said.
According to the 500-page declassified summary of the Senate Intelligence Committee's findings, the first CIA briefing with Bush on the interrogation techniques was on April 8, 2006.
Some of the prisoners -- including Abu Zubaydah, allegedly Osama Bin Laden's right-hand man, and Abd al-Rahim al-Nashiri, who allegedly led Al-Qaeda operations in the Gulf -- were subjected to the torture starting in 2002, it said.
China and Iran, whose own human rights records have often been criticized by Washington, denounced the abuses -- but so did Germany and the new pro-US leader of Afghanistan.
"Such a gross violation of our liberal, democratic values must not happen again," German foreign minister Frank-Walter Steinmeier said, reflecting the embarrassment of Washington's European allies.
America's great power rival China -- often on the end of US censure for its rights record -- was equally unimpressed.