Vyas is known for her stint in head of NCW from 2005 to 2011 when she pursued several high profile cases of atrocities against women. As a member of the Public Accounts Committee, she was very active in defending the government during the proceedings in the 2G spectrum allocation case.
Vyas has mainly been active in the Congress, having served as a former Pradesh Congress Committee Chief of Rajasthan from 2001-04 and head of the AICC Media Department.
A poet and author, Vyas became an MLA in 1985. She also served as a minister in the Rajasthan government.
Vyas was elected to the Lok Sabha for the first time in 1991 from Udaipur and was a Deputy minister in the Narasimha Rao government.
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Many Congressmen had expected that Vyas will be made a minister in the Manmohan Singh government in 2009.
A good orator, Vyas often leads the debate on behalf of the Congress on important issues in Parliament.