US District Court Judge Jeffrey White in Oakland said Liew, a naturalised US citizen, had "turned against his adopted country over greed."
A jury previously convicted the 56-year-old Liew of receiving USD 28 million from companies controlled by the Chinese government in exchange for DuPont Co's pigment technology for making cars, paper and a long list of everyday items whiter.
Along with the USD 28.3 million Liew was ordered to forfeit and pay to DuPont, the engineering company launched by him and his wife was fined USD 18.9 million.
White noted that US authorities had managed to trace USD 22 million of the USD 28 million received by Liew to various Singapore and Chinese companies controlled by Liew's in-laws before losing the trail.
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"We'll never get it," White said. "It has been spirited out of the country."
Liew and his wife, Christina Liew, launched a small California company in the 1990s aimed at exploiting China's desire to build a DuPont-like factory to manufacture the white pigment known as titanium dioxide.
The Liews hired retired DuPont engineers and, according to the FBI, paid them thousands of dollars for sensitive company documents laying out a process to make the pigment.
Except for a few months of release on bail, Liew has been in jail since his arrest in 2011. Wearing yellow jail garb and with his wife and family looking on from the gallery, Liew apologised for his actions.
"There are many things I would have liked to have done differently," Liew told the judge. "I regret my actions." Liew was born on a farm in Malaysia to Chinese parents and went on to earn advanced degrees in chemical engineering.
Liew's wife has pleaded not guilty to obstruction of justice and other charges.