Mane, a former driver with state transport, had mowed down nine people in Pune in a fit of maniacal driving in January 2012.
The division bench of Justices V M Kanade and P D Kode is hearing state's plea for confirmation of his death sentence, as well as his appeal against the sentence.
The court today also sought to know from the government if there was any possibility of the convict being reformed if his life was spared.
On January 25, 2012, Mane had hijacked an empty bus from Swargate depot and drove it like a madman until the police and some passers-by caught up with him and stopped him.
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While the state has sought confirmation of death penalty saying that he committed a serious crime against the society, Mane's lawyer, advocate Jagdish Mane, sought leniency, considering that Santosh has a wife, two children and parents to look after and also because he is "mentally sick".
The High Court has already upheld his conviction.
The defence also pleaded insanity and sought Santosh's re-examination by a psychiatrist but the High Court turned down the plea. The arguments will continue tomorrow.