"Our economy must be protected, our products must reach markets and our jobs must be preserved," Leitch told a press conference yesterday.
Her remarks came after the Teamsters union -- representing some 3,000 workers at Canadian National Railway, or CN -- gave 72 hours strike notice.
The Conservative government, she said, intends to introduce legislation to ensure that "CN stays on track."
Strike notice was given after CN workers rejected a tentative labour contract reached last fall.
Ottawa previously intervened to also prevent or end work stoppages at Air Canada and at Canadian Pacific Railway in 2012.