Researchers from the Stockholm Environment Institute used a mathematical model to estimate the Keystone XL pipeline's potential for atmospheric pollution.
Unlike calculations by the US State Department, they took into account a possible consumption rise in line with production, the pair wrote in the journal Nature Climate Change.
It was not clear, though, what the production increase was likely to be.
Using basic supply-and-demand economic principles and assuming a rise in production, the team calculated the pipeline would yield greenhouse gas emissions of 100-110 million tonnes of carbon dioxide equivalent (MtCO2e) per year -- "four times the upper State Department estimate" of 27.4 MtCO2e, they said.
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US President Barack Obama has said the pipeline could only be approved if it "does not significantly exacerbate the problem of carbon pollution".
The research team said that for every barrel of increased production, global oil consumption would increase by 0.6 barrels "owing to the incremental decrease in global oil prices".
This, in turn, would pump out more Earth-warming carbon dioxide emissions -- estimated at about 36 billion tonnes for 2013.
"The State Department's assessment has overlooked the pipeline's potentially most significant GHG impact: increasing oil consumption as the result of increasing supplies and lowering prices.