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Cannabis could help treat obesity-related diseases: Scientists

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Press Trust of India London
Last Updated : Jan 24 2013 | 2:11 AM IST

Test in animals have already shown the compounds -- THCV and cannabidiol -- can help treat type two diabetes while also helping to reduce levels of cholesterol in the blood stream and fat in key organs like the liver.

Now, scientists are conducting clinical trials in about 200 patients in the hope of producing a drug that can be used to treat patients suffering from "metabolic syndrome", where diabetes, high blood pressure and obesity combine to increase the risk of heart disease and stroke.

Dr Steph Wright, director of research and development at GW Pharmaceuticals which is developing the drugs, said: "We are conducting four Phase 2a clinical trials and we expect some results later this year."

"The results in animal models have been very encouraging. We are interested in how the drugs effect the fat distribution and utilisation in the body as a treatment for metabolic diseases," Wright was quoted as saying by the Daily Telegraph.

"Humans have been using these plants for thousands of years so we have quite a lot of experience of the chemicals in the plants," he added.

Although cannabis is an illegal drug, GW Pharmaceuticals has obtained a license to grow the plant in specially-designed greenhouses on a secret facility in the south of England. It produces plants that were bred to express different quantities of compounds known as cannabinoids. It's already developing drugs that can treat multiple sclerosis and epilepsy.

Although cannabis is better known for inducing hunger in those who smoke it, known as the munchies, when the scientists examined two compounds, THCV and cannabidiol, they were found to have an appetite suppressing effect.

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This effect only lasts for a short time, however. When the scientists looked closer, they found the compounds also had an impact on the level of fat in the body and its response to insulin that controls the sugar levels in the blood.

Tests in mice showed the compounds boosted the animals metabolism, leading to lower levels of fat in their livers and reduced cholesterol in their blood stream.

It has raised hopes that the drugs can be developed into treatments for obesity related diseases and type 2 diabetes.

  

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First Published: Jul 08 2012 | 4:36 PM IST

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