A senior official said it could have escaped late in the night and the incident came to light only this morning. An operation is on to track and recapture it.
"We will come to know about it only afterinvestigation... Once the probe is over, we will fix the responsibility and initiate action," he said.
The leopard had entered a private school near Varthur here on February 7 causing panic in and around the area.
Meanwhile, speaking to reporters in Mysuru, Chief Minister Siddaramaiah said he would seek information from forest departmentofficials about the leopard's escape.
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"I will seek details of the animal's escape. I will talk to the forest department officials and find out the reason," he said.
Officials said there were three layers of barriers and it was difficult (for the animal) to escape by itself.
"We will get to how the leopard escaped only after a thorough investigation," they said.