The blast rocked a street in the Akrama neighbourhood mostly inhabited by members of the Alawite minority to which President Bashar al-Assad belongs, the Syrian Observatory for Human Rights said.
"At least eight people died when a mini-bus exploded on the edge of the Akrama neighbourhood," the head of the Britain-based monitor, Rami Abdel Rahman, told AFP.
The attack, for which there was no immediate claim, was confirmed by Syrian state media and officials.