"Seven killed and others injured according to a first toll in a terrorist car bomb explosion in Wadi Dahab in Homs," state television said.
The blast was also reported by the Syrian Observatory for Human Rights, a Britain-based monitor, which said the neighbourhood is majority Alawite -- the sect to which President Bashar al-Assad belongs.
In May, Syrian government forces retook control of almost all of Homs, once dubbed the "capital of the revolution," after a deal allowing the withdrawal of rebel fighters trapped under siege.
On May 25, 12 people were killed in a twin car bomb attack in the city's Zahra neighbourhood, just days after a similar attack there killed 100 people.
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Those attacks were claimed by Al-Nusra Front, the official affiliate of Al-Qaeda in Syria.
Meanwhile north of Homs, the Observatory said at least 18 rebels, including fighters from Al-Nusra, were killed battling regime forces near the village of Umm Sharshuh.
Today, regime warplanes carried out air raids on the village, which rebels captured a day earlier.