Football legend Pele is tipped to ignite the Olympic flame at Rio's iconic Maracana Stadium in Friday's opening ceremony, as the four-yearly celebration of sporting endeavour arrives in South America for the first time.
Olympic chiefs will hope the ceremony marks the start of a 17-day carnival of sport, a feast of drama framed by a Rio backdrop of breathtaking natural beauty.
Jamaican sprint king Usain Bolt will compete under the gaze of the Christ the Redeemer statue, sailors will duel in the shadow of Sugarloaf Mountain while the golden sands of Copacabana will host the spiritual homecoming of the beach volleyball tournament.
When Rio successfully won the race for the Games in 2009, the 2016 Olympics looked set to be the crowning glory of a dynamic, newly-confident Brazil.
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But a brutal recession, double-digit unemployment, fears about the mosquito-borne Zika virus, embarrassing infrastructure stumbles and a political crisis that led to the impeachment of President Dilma Rousseff have all but extinguished the euphoria that greeted the vote victory.
More than one million tickets, or 20 percent of the total, including for coveted events such as the men's 100-metres final, remained unsold as of Wednesday.
"You go into a hospital and can't find a doctor or medicines."
"It will bring some happiness, yes it will," added pharmacist Edna Carla Assis, 31. "But nothing more."
Several ambitious plans to transform Rio have long since been abandoned, including a pledge to clean up the city's filthy Guanabara Bay.
That failure means athletes in Olympic sailing and windsurfing events will be forced to compete in a toxic soup of raw sewage from half of the city's population.
Brazilian officials insist that the threat of infection is near zero in what is one of the coolest times of the year.
A vast security blanket of 85,000 military personnel and police -- twice the number on duty at the 2012 London Games -- will be draped over the city to ward off the threat of terror attacks.
Danish, Chinese and Australian delegations have already reported thefts from team members since arriving in Brazil, while in May members of Spain's sailing team were mugged at gunpoint.
A devastating report by a World Anti-Doping Agency (WADA) investigative panel issued last November detailed a state-supporting doping program that harked back to the worst steroid scandals of the Cold War-era.
The International Association of Athletics Federations (IAAF) subsquently banned Russian track and field athletes from all international competition for six months.
The IAAF later extended that suspension to cover the Olympics after ruling that Russia had not taken sufficient steps to overhaul its anti-doping regime.
The fallout from the drugs scandal should give way to several compelling sporting storylines once the action gets under way.
Once again, Jamaican superstar Bolt could electrify his sport when he attempts to defend his 100m, 200m and 4x100m relay crowns in the blue riband track and field event.
All eyes will turn to the Olympic swimming pool in the opening week when US star Michael Phelps returns for his swansong.
Gymnastics meanwhile could see the coronation of a new darling with America's teenage star Simone Biles while football superstar Neymar bids to inspire Brazil to a first ever Olympic gold medal.
New sports making their debut in Rio will include seven-a-side rugby and golf.
As always, however, while millionaire globally renowned stars like Bolt, Phelps and Neymar chase gold, it is the lesser known athletes who will relish their moment in the spotlight.
They include Yusra Mardini, an 18-year-old from Syria who less than a year ago was forced to swim for her life during a perilous journey across the Mediterranean as she fled her war-torn homeland.
Another refugee athlete, judoka Yolande Mabika, said simply: "This is not just a struggle for sport -- it's a struggle for life.