CAS upheld FIFA's appeal for a longer sentence after Angulo received a one-year suspension from South American soccer body CONMEBOL.
The 22-year-old Angulo is banned until July 19, 2020. CAS said its judging panel found the "facts submitted by the player did not match with the evidence produced by the scientific experts."
A detailed verdict will be published at a later date. Angulo played in both legs of the continental championship final for Ecuador's Independiente del Valle, which lost 2-1 on aggregate to Atletico Nacional of Colombia.