The new campaign aims to drive donations to the charity's winter appeal which focuses on the children whose lives have been affected by the ongoing conflict in Syria, reported Femalefirst.
Unicef is encouraging the public to show their support for the campaign by taking part in their #HappyBlueYear video challenge by visiting the Unicef website or downloading the Happy Blue Year app.
People can then record a video of themselves singing along to Unicef's catchy tune with the specially created blue mouth.
Unicef UK Ambassador Cat - who is pregnant with her first child - said: "I love seeing in the New Year with my friends and family, watching the clock tick down to midnight and making our resolutions for the year ahead.