The 72-year-old actress will receive the honour at the event's opening on November 29, said The Hollywood Reporter.
Three of Deneuve's films from her 58-year career will be screened as a tribute during the event, Turkey's top film festival and longest-running annual cinema event.
The films to be screened are her most recent, Jaco Van Dormael's "The Brand New Testament", Jacques Demy's 1964 classic "The Umbrellas of Cherbourg" and Regis Wargnier's "Indochine".
Deneuve has played roles in around 130 films since her debut at the age of 14 in "The Twilight Girls".
The International Antalya Film Festival will run through December 6.