The series, starring Poppy Montgomery as a detective with photographic memory, was initially cancelled by the network after only one season in 2012, reported Deadline.
However, CBS reversed its decision and revived the show for a 13 episode second season in 2013.
After a successful summer run, CBS commissioned a third season, which finished in September.
The crime drama was cancelled again on October 10.
Legal drama 'Reckless' has also been cancelled after one season, while 'Under The Dome' and Halle Berry's 'Extant' have both been renewed.