CCI has the mandate to keep a tab on unfair business practices across sectors, while mergers and acquisitions beyond a certain threshold also requires its approval.
"CCI decides 29 combination cases in December 2015 - highest number of cases ever decided in a month," CCI said in a tweet today.
In July, CCI had revised its combination regulations as part of its efforts to make the process simpler and more transparent.
According to the regulator, the amendments provide greater clarity and certainty with respect to M&A filings and will help in avoiding undue delays in the approval process.
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The regulator also gave its nod to the acquisition of wealth management business of RBS by Sanctum Wealth and the acquisition of animal health business of Novartis by Eli Lilly.
Besides, the regulator during the month also sought comments from the public on India's largest multiplex chain PVR Ltd's proposed Rs 500 crore acquisition of DT Cinemas.
CCI also introduced electronic filing facility during December, making it simpler for entities to submit information related to mergers and acquisitions.
In August, CCI Chairman Ashok Chawla had said there was at least 15-20 per cent increase in filings. M&A filings for this year are likely to be 20 per cent more than the previous year, he had said.