Trump, a former reality star, who has hosted "The Apprentice", swept Clinton in battleground states like Florida, North Carolina and Ohio.
Many celebrities had openly backed Clinton and they have now taken to social media to share their despair.
Kunal Nayyar, the Indo-American star of "The Big Bang Theory" expressed fear over Trump's election win.
"Never in 15 years of living In this country have I ever felt afraid to look like I do. #immigrant," he wrote.
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"The positive element from all this is that we can no longer pretend that we are free of racism & sexism. The question is, what do we do now?" wrote actress Jessica Chastain.
Actress Amanda Seyfried said with this result, US has hit "rock bottom".
"Maybe this is rock bottom and there's no where to go but up," she posted.
"Well this is utterly terrifying," wrote pop star Ariana Grande.
"Captain America" star Chris Evans called Trump's victory "embarrassing."
"This is an embarrassing night for America. We've let a hatemonger lead our great nation. We've let a bully set our course. I'm devastated."
TV producer Shonda Rhimes, who has been vocal against Trump's Presidential bid, expressed her disappointment.
"Really, people? ANYONE can be President? ANYONE? ANY-ONE? No but seriously: THIS many of you don't mind the body-part grabbing xenophobic man who says "there's my black over there?"
Comedian-filmmaker Seth MacFarlane tweeted, "I truly cannot visualize the rambling, incoherent creature I saw at the debates now addressing the nation from the Oval Office."
Commenting on Trump's stand on minorities, actor Will Arnett wrote, "How do we explain this to future generations of women? And minorities?#weshouldbeashamedofourselves."
"We are staring into the face of our darkest self America. Why does it have to have a dyed combover?" "Nashville" actress Connie Britton said.
Trevor Noah added, "5 steps forward. 10 steps back."
"Where is #OliviaPope when you need her?" singer Demi Lovato said, referring to Kerry Washington's political crisis manager character from "Scandal".
Sports Illustrated model Chrissy Teigen tweeted: "I cannot believe this is real. I can't believe Donald Trump has the honor of winning ANY state at all."