Oscar-winning Austrian actor Christoph Waltz and Matt Damon are also among the stars lending their faces and voices to the two-minute video plea by the anti-nuclear campaign group Global Zero.
"The message from national security experts and citizens around the world is clear: the only way to eliminate the global nuclear danger is to eliminate all nuclear weapons," says "Basic Instinct" star Douglas.
"It's time to set the world's course to zero," he adds.
Global Zero co-founder Matt Brown said the video was intended to appeal to US President Barack Obama and his Russian counterpart Vladimir Putin, due to meet on the sidelines of the G8 summit Monday and Tuesday.
"To set the world's course to zero nuclear weapons, President Obama will have to go beyond the bilateral process President (Ronald) Reagan started of US-Soviet/Russian arms reductions and bring the other leading nuclear powers into international arms negotiations for the first time in history," he said.