"Protectionism will only lead to a loss of prosperity for all," warned European Central Bank board member Yves Mersch on Friday.
The Luxembourger's words came just three weeks after US President Donald Trump took office with a speech that hammered home his "America first" stance, fuelling concern that the US billionaire plans to shake up global trade rules.
Even before the inauguration, Trump was talking up tariffs, telling a German interviewer he would slap a border tax on BMW cars if the firm went ahead with the construction of a plant in Mexico.
"Uncertainty surrounds the direction of US macroeconomic policies with potential global spillovers," the Reserve Bank of India worried in a statement last week after leaving its main interest rates unchanged.
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"Global trade remains subdued due to an increasing tendency towards protectionist policies and heightened political tensions," it noted.
In many advanced economies, central banks are free of government control, using their independent economic judgement to set interest rates and safeguard financial stability while remaining above the political fray.
Now "a further step has clearly been taken", he said, as monetary policymakers brace for the uncertainties of Trump's economic policies and the upcoming Brexit divorce negotiations, expected to take Britain out of the EU's single market for goods, services, capital and labour.
Bank governors' newfound readiness to pass comment is more a reflection that protectionism "wasn't much of an issue to talk about until recently" than staking out of a political position, economist Ben May of Oxford Economics told AFP.
As in Britain, where voters had "had enough of experts" according to Brexit campaigner Michael Gove, governments may disagree with their central bank's advice for reasons unrelated to economics and take actions that limit trade.