In an interview, the 39-year-old actress said she would love to add another to her family, reported Ace Showbiz.
"Yeah. I mean, I'm so open to anything in my life. I was never like, 'Oh god no just one.' I was always kind of open to whatever kind of happens," she said.
And when it comes to her three-year-old adopted son Jackson, Theron recalled how he didn't even recognise her when he saw her on a billboard.
"We were driving the other day... And the billboard was there and I had one of those actor moments where I was like, 'Hey, that's your mom up there, by the way,' " she said.
The beauty is currently dating actor Sean Penn with whom she shares screen in "The Last Face".