The 37-year-old actress, who regularly dazzles with her red carpet looks and her timepiece and fragrance ads, is following in the footsteps of Katie Holmes after teaming up with her stylist, Leslie Fremar, to design the new Theron Jeans line, the Hollywood Reporter said.
The two women are planning to mass-market the collection for major retailers.
Holmes joined forces with her fashion adviser, Jeanne Yang, to create the Holmes & Yang label in 2009.
Theron has already made her mark in the shoe world - she has an eco-friendly line of footwear with the TOMS Shoes brand, the proceeds of which benefit her non-profit charity, the Charlize Theron Africa Outreach Project, which aids impoverished children in her native South Africa.