Dr Aleida Guevara March, Guevara's eldest daughter who often acts as the family's spokesperson, also accused the US of using war to crush the strength of peoples.
"The man has so much power to destroy humanity, and we are part of that humanity. That is the problem. That he has the power, and no conscience," 57-year-old Aleida told The Week in an interview in Havana, the capital of Cuba.
When asked where she sees Cuba 10 years down the line, Aleida responded, "It depends a lot on the madness of the current president of the United States."
"It is time to wake up. We have to wake up, because we don't have much time left," Aleida was quoted as saying.
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During his election campaign, Trump had criticised then President Barack Obama's deal with Cuba in 2014 to re- establish ties that were cut in 1961 and vowed to push back the detente.
Aleida said the blockade has affected the fields of diagnostics and technology.
"We had to look for alternatives, and natural cure was one. We also developed the concept of preventive care. It is easier to prevent a disease than to cure it, and that is the basic principle of Cuban medicine," she said.
She hailed her father Che Guevara as a man who knew how to love and said that was why he was a great communist.
"I remember him as very demanding as far as discipline was concerned, at the same time very loving," she added.
"I remember visiting Calcutta, Hyderabad and Calicut, and the people were friendly," she said.