The Bojan Djordjic-led Chennaiyin were unbeaten in the competition before being hosted by Delhi Dynamos, who handed them a sound 4-1 thrashing.
Mumbai, on the other hand, are struggling to find their rhythm and are third from bottom in the points table with a win and two losses, the most recent being a 0-2 defeat against NorthEast United on home turf.
If French import Anelka plays tomorrow and manages to hit the stride, Chennai's defence, which Delhi penetrated with ease in the previous match, would be in for another massive test and it would be interesting to see how the likes of Mikael Silvestre tie him down.
Chennai, managed by Italian World Cup winner Marco Materazzi, do not lack in attacking firepower either. Brazilian signing Elano Blumer, the youngest marquee player in the ISL who has played for Manchester City, has been a prolific contributer to the team's cause, scoring in every match so far.
He did not play the full 90 minutes against NorthEast United owing to a niggle but is expected to be back to full fitness tomorrow.
Adding to Mumbai's strike force is diminutive Indian Subhash Singh, who has one goal to his credit so far in the tournament.