The clinical trial will provide crucial evidence about the effectiveness of a screening programme for the country's most lethal cancer, which claims more than 8,000 lives a year.
People at a high risk of developing lung cancer, predominantly heavy smokers over 55, will undergo regular computer tomography (CT) scans in the trial to see if it can detect the disease before it becomes deadly.
"The cure rate is very low because 75 per cent of lung cancers have already spread by the time they are detected," said Lou Irving, associate professor at Royal Melbourne Hospital in Australia.
"If you can pick it up when it is the size of a peanut there is then the chance to use surgery, which, in very early disease, has a cure rate of 85 per cent," he added.