Chinese foreign ministry spokesman Lu Kang said China had asked Pakistani authorities to "take all necessary measures and do their best to rescue the kidnapped Chinese."
Lu added that the two governments were coordinating to ensure the safety of other Chinese citizens in Pakistan.
Pakistani police were searching for the two teachers from a private language school after they were abducted in the city of Quetta yesterday.
Gunmen dressed as police stopped the couple's car and shot and wounded a man who intervened after he rescued a third person who was in the car, according to Pakistani police and China's official Xinhua news agency.
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Thousands of Chinese nationals work in Pakistan and have sometimes been targeted in attacks by anti-government militants.
China is a longtime ally of Pakistan and is currently building a network of roads and power plants under a project known as the China-Pakistan Economic Corridor.
Gunmen attacked a highway construction site that is part of the economic initiative earlier this month, killing at least 10 Pakistani workers.
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