Xinjiang is the homeland of the Uighurs - a traditionally Muslim group, many of whom complain of cultural and religious repression and discrimination.
The area has been hit by a wave of deadly unrest, while authorities have stepped up already-strict controls and organised mass rallies of thousands of military police to indicate Chinese resolve in crushing security threats.
The new regulations, which will come into force on Saturday, outline prohibitions on growing "abnormal" facial hair or wearing robes that cover the whole body and face.
China has for years blamed exiled Uighur "separatists" for a series of violent attacks in Xinjiang and warned of the potential for militants to link up with global jihadist groups. But many independent experts have doubted the strength of overseas Uighur groups, with some saying China exaggerates the threat to justify tough security measures.
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Previously Chinese authorities have restricted granting passports to Uighurs and adopted measures limiting or banning prayer at home, religious education for children, and fasting during Ramadan, which rights groups say has fuelled anger in the region.
Earlier this month Islamic State militants of the Uighur minority released a video vowing to return home and "shed blood like rivers" in China, in what experts said marked the first IS threat against Chinese targets.
In the video, a Uighur fighter issued the threat against China just before executing an alleged informant.
In one violence-wracked corner of Xinjiang, authorities are offering rewards of up to 5 million yuan (USD 730,000) to those who expose terror plots or "struggle, kill, wound, or subdue" any attackers.