"Boeing is delighted with China Eastern Airlines's decision to purchase 50 Next-Generation 737-800s," the company said in a statement.
The Shanghai-based airline plans to use the single-aisle 737s, the world's best-selling airplane, for operation by its subsidiary China United Airlines, it said.
China Eastern has a fleet of more than 430 long-haul and short-haul aircraft serving nearly 80 million travelers annually, according to its website.
A member of the SkyTeam airline alliance, China Eastern said it ranks among the world's top five airlines by passenger transportation volume.