An inspection by the Central Commission for Discipline Inspection found Wei Hong committed "serious violations of discipline" the official Xinhua news service said, using a euphemism for corruption, and was "disloyal and dishonest to the Party".
"He attempted to subvert the investigation and refused to confess, seriously violating the Party political and organisational code of conduct," Xinhua said, adding that he had "interfered with judicial activities".
As a consequence, he was stripped of the governorship and his role as the vice-secretary of the Communist Party's office in Sichuan.
One of Zhou's power bases was Sichuan, in China's southwest with a population of some 80 million. A number of senior officials there have been investigated in recent years.