The reserve covers an area of 2,500 square kmsand aims to limit light pollution by stepping up protection of dark-sky resources for education and tourism development.
It was jointly launched by the China Biodiversity Conservation and Green Development Foundation and the regional government of Tibet.
Wang Wenyong, head of the legal affairs department with the foundation, told media that the launch of the preserve is only the first step in protecting the area from light pollution.
The reserve will also try to seek accreditation from the International Dark-Sky Association, a nonprofit organisation based in the United States that is devoted to preserving and protecting the night time environment and dark skies globally.
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Ngari is among the best sites for astronomical observation on earth, due to its high altitude and large number of cloudless days throughout the year.
However, the recent inflow of people from other areas has given rise to increasing urbanization, and thus the associated risk of more light pollution.
"If we do not take action now to preserve the area, we risk losing one of the best astronomical sites on earth," Wang said.